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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SETD1A
All Species:
5.15
Human Site:
Y646
Identified Species:
8.72
UniProt:
O15047
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15047
NP_055527.1
1707
186034
Y646
D
G
P
P
P
P
E
Y
P
P
P
P
P
P
P
Chimpanzee
Pan troglodytes
XP_523492
1707
185692
Y646
D
G
P
P
P
P
E
Y
P
P
P
P
P
P
P
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_848999
1330
145541
Y382
Y
Y
E
S
W
N
R
Y
Q
R
H
A
S
Y
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFT2
1985
215333
P699
P
G
F
P
M
P
P
P
L
P
P
P
P
P
P
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506028
1287
141359
P339
G
D
Q
K
R
L
R
P
S
T
S
V
D
D
D
Chicken
Gallus gallus
Q5F3P8
2008
223067
H714
P
P
P
P
P
P
T
H
P
A
V
T
V
P
P
Frog
Xenopus laevis
Q66J90
1938
216239
F666
P
P
P
P
Q
S
G
F
P
M
P
P
P
L
P
Zebra Danio
Brachydanio rerio
Q1LY77
1844
204122
D694
M
M
H
F
L
P
V
D
L
L
S
S
L
P
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001015221
1641
188364
S644
A
E
Y
K
S
I
M
S
S
Y
M
Y
S
H
S
Honey Bee
Apis mellifera
XP_395451
1406
159180
P458
K
D
P
P
P
P
P
P
P
D
D
D
R
M
S
Nematode Worm
Caenorhab. elegans
Q18221
1507
171664
P559
E
T
P
P
P
P
P
P
K
G
H
P
S
V
H
Sea Urchin
Strong. purpuratus
XP_791552
1963
220543
K731
L
P
S
V
E
A
D
K
V
S
Q
S
E
G
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38827
1080
123894
Q132
E
S
A
L
L
L
Q
Q
R
P
P
S
V
L
R
Red Bread Mold
Neurospora crassa
Q8X0S9
1313
145607
R365
P
A
H
Q
A
A
R
R
A
V
R
G
M
H
G
Conservation
Percent
Protein Identity:
100
99.5
N.A.
73.2
N.A.
37
N.A.
N.A.
27.7
34.5
34.1
36.7
N.A.
25.6
24.6
20.9
23.7
Protein Similarity:
100
99.5
N.A.
74.7
N.A.
49.5
N.A.
N.A.
38.7
47.5
48.6
50.7
N.A.
41.3
39.6
35.8
39.2
P-Site Identity:
100
100
N.A.
13.3
N.A.
60
N.A.
N.A.
0
46.6
46.6
13.3
N.A.
0
33.3
33.3
0
P-Site Similarity:
100
100
N.A.
13.3
N.A.
60
N.A.
N.A.
0
53.3
53.3
13.3
N.A.
0
33.3
40
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.7
22.2
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
33.8
36.5
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
0
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
8
0
8
15
0
0
8
8
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
15
15
0
0
0
0
8
8
0
8
8
8
8
8
8
% D
% Glu:
15
8
8
0
8
0
15
0
0
0
0
0
8
0
8
% E
% Phe:
0
0
8
8
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
8
22
0
0
0
0
8
0
0
8
0
8
0
8
8
% G
% His:
0
0
15
0
0
0
0
8
0
0
15
0
0
15
8
% H
% Ile:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
0
0
15
0
0
0
8
8
0
0
0
0
0
0
% K
% Leu:
8
0
0
8
15
15
0
0
15
8
0
0
8
15
0
% L
% Met:
8
8
0
0
8
0
8
0
0
8
8
0
8
8
0
% M
% Asn:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% N
% Pro:
29
22
43
50
36
50
22
29
36
29
36
36
29
36
43
% P
% Gln:
0
0
8
8
8
0
8
8
8
0
8
0
0
0
8
% Q
% Arg:
0
0
0
0
8
0
22
8
8
8
8
0
8
0
8
% R
% Ser:
0
8
8
8
8
8
0
8
15
8
15
22
22
0
15
% S
% Thr:
0
8
0
0
0
0
8
0
0
8
0
8
0
0
0
% T
% Val:
0
0
0
8
0
0
8
0
8
8
8
8
15
8
0
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
8
8
0
0
0
0
22
0
8
0
8
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _